141 articles - From Friday Mar 31 2023 to Friday Apr 07 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gut |
Joint Asian Pacific Association of Gastroenterology (APAGE)-Asian Pacific Society of Digestive Endoscopy (APSDE) clinical practice guidelines on the use of non-invasive biomarkers for diagnosis of colorectal neoplasia. Future research to inform clinical applications are discussed alongside objective measurement of research priorities. This joint APAGE-APSDE practice guideline is intended to provide an up-to-date guide to assist clinicians worldwide in utilising non-invasive biomarkers for CRC screening; it has particular salience for clinicians in the Asia-Pacific region. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
Comparative Speed of Early Symptomatic Remission with Advanced Therapies for Moderate-Severe Ulcerative Colitis: A Systematic Review and Network Meta-Analysis. In a systematic review and network meta-analysis, upadacitinib was most effective in achieving early symptomatic remission, whereas ozanimod was relatively slower acting. |
| Gastrointest Endosc |
Incidence, Severity and Mortality of Post ERCP Pancreatitis: An Updated Systematic Review and Meta-Analysis of 145 Randomized Controlled Trials. The overall incidence of PEP is 10.2% but 14.1% among high-risk patients based on this systematic review of the placebo or no stent arms of 145 RCTs and has not changed between 1977-2022. Severe PEP and mortality from PEP are relatively uncommon. |
| J Neurogastroenterol Motil |
Small Intestinal Bacterial Overgrowth Complicating Gastrointestinal Manifestations of Systemic Sclerosis: A Systematic Review and Meta-analysis. There is a 10-fold increased prevalence of SIBO in SSc, with similar SIBO prevalence rates in SSc-subtypes. Antimicrobial therapy of SIBO-positive SSc-patients with diarrhea should be considered. However, the results must be interpreted with caution due to substantial unexplained heterogeneity in the prevalence studies, and the low sensitivity and specificity of the diagnostic tests suggesting that the reliability of the evidence may be low. |
| Neurogastroenterol Motil |
A systematic review and meta-analysis on the prevalence and clinical characteristics of dysphagia in patients with dermatomyositis. Our findings showed that dysphagia affects one in three patients with DM or JDM. However, the documentation on the diagnosis and management of dysphagia in the literature is inadequate. Our results highlighted the need to use both clinical and instrumental assessments to evaluate swallowing function in this population. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Disturbances in sodium and chloride homeostasis predict outcome in stable and critically ill patients with cirrhosis. Hypochloremia is associated with increased mortality in clinically stable and critically ill patients with cirrhosis independently of MELD including serum sodium. |
Risk of colorectal neoplasia according to histologic disease activity in patients with inflammatory bowel disease and colonic post-inflammatory polyps. After controlling for histologic activity, PIPs do not increase the risk of CRN in IBD patients. Histologic activity rather than PIPs should be considered in the risk assessment of CRN. |
The combination of the enhanced liver fibrosis and FIB-4 scores to determine significant fibrosis in patients with nonalcoholic fatty liver disease. The combination of ELF and FIB-4 may provide practitioners with easily obtained information to risk stratify patients with NAFLD who could be referred to specialists or for enrollment in clinical trials. |
The prevalence and burden of Rome IV faecal incontinence in ulcerative colitis: A cross-sectional study. The prevalence of FI in UC is high, even in remission, and associated with significant psychological distress, symptom burden and impaired QoL. These findings highlight the urgent need for further research and development of evidence-based treatments for FI in UC. |
| Am J Gastroenterol |
Quality of life in patients with definite chronic pancreatitis: a nationwide longitudinal cohort study. This nationwide study provides insight into the dynamics of physical and mental QoL in patients with CP over time. Important and potentially influenceable factors to improve QoL are nutritional status, exocrine pancreatic function, employment status, and patients' coping strategy. |
Radiotherapy Improves Survival of Patients with Lymphovascular Invasion in pT1b Esophageal Squamous Cell Cancer after Endoscopic Submucosal Dissection. Adjuvant radiotherapy could improve survival in pT1b ESCC with LVI+ other than LVI- after ESD. Selective adjuvant radiotherapy based on LVI status achieved survival rates similar to those of the general population. |
Safety, Pharmacokinetics, & Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-associated Hepatitis. Larsucosterol was well tolerated at al 3 doses in AH subjects without safety concerns. Data from this pilot study showed promising efficacy signals in AH subjects. Larsucosterol is being evaluated in a Phase 2b multicenter, randomized, double-blinded, placebo-controlled (AHFIRM) trial. |
| Clin Gastroenterol Hepatol |
Adding inflammatory markers and refining NIAAA criteria improve diagnostic accuracy for Alcohol-associated Hepatitis. NIAAA criteria are suboptimal for the diagnosis of AH. The proposed NIAAAm-CRP criteria may improve sensitivity, specificity and accuracy for non-invasive diagnosis of AH in patients with ArLD. |
ASSOCIATION BETWEEN THE PRESENCE OF METABOLIC COMORBIDITIES AND LIVER-RELATED EVENTS IN PATIENTS WITH CHRONIC HEPATITIS B. Metabolic comorbidities in CHB patients are associated with increased risk for liver-related events, with the highest risk observed in patients with multiple comorbidities. Findings were consistent in various clinically relevant subgroups underscoring the need for thorough metabolic assessment in patients with CHB. |
Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease. Routine testing of anti-HBs titers may not be indicated for fully vaccinated IBD/CD patients. Additional studies are needed to confirm these findings in other settings and populations. |
Longitudinal Fecal Calprotectin Profiles Characterize Disease Course Heterogeneity in Crohn's Disease. Our analysis demonstrates a novel approach to characterizing the heterogeneity of Crohn's disease by using fecal calprotectin. The group profiles do not simply reflect different treatment regimens and do not mirror classical disease progression endpoints. |
| Endoscopy |
High-quality colonoscopy: using Textbook Process as a composite quality measure. This study proposes a new composite measure for colonoscopy Textbook Process. TP gives a comprehensive summary of performance and demonstrates significant variation between endoscopists, illustrating the potential benefit of TP as measure in future quality assessment programs. |
| Gastroenterology |
Comparative Effectiveness of Anti-TNF in Combination with Low Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: a Pragmatic Randomized Trial. Among adalimumab but not infliximab initiators, PCD patients treated with methotrexate combination therapy experienced a 2-fold reduction in treatment failure with a tolerable safety profile. |
| Gastrointest Endosc |
Benefits of EUS-Guided Gastroenterostomy Over Surgical Gastrojejunostomy in the Palliation of Malignant Gastric Outlet Obstruction: A Large Multicenter Experience. This is the largest study showing EUS-GE can be performed among nutritionally deficient patients without impacting the technical and clinical success compared to SGJ. EUS-GE is associated with fewer AEs while allowing sooner resumption of diet and chemotherapy. |
Characterization of endoscopic features and histology of a distinct mucosal transition zone on the ileocecal valve. This is the first description of the normal transitional zone of mucosa on the ICV. This zone has unique endoscopic features that should be recognized by colonoscopists, and which can potentially create difficulty in identifying the margins of adenomas located on the ICV. |
Diagnostic Accuracy and Safety of Endoscopic Ultrasound-Guided End-cutting Fine-needle Biopsy needles for tissue sampling of Abdominal and Mediastinal Lymphadenopathies: a prospective multicenter series. EUS-FNB with new end-cutting needles is a valuable and safe method to diagnose LA. The high quality of histological cores and the good amount of tissue allowed a complete immunohistochemical analysis of metastatic LA and precise subtyping of the lymphomas. |
Efficacy and safety of combined endoscopic mucosal resection and endoscopic full-thickness resection (Hybrid-EFTR) for large non-lifting colorectal adenoma. Hybrid-EFTR is safe and effective for advanced colorectal adenoma which cannot be approached by EMR or EFTR alone. Hybrid-EFTR expands the indication of EFTR substantially in selected patients. |
Predictors of stricture after non-circumferential endoscopic submucosal dissection of the esophagus and single-dose triamcinolone injection immediately after the procedure. We identified predictors of stricture after ESD and local TA injection. Local TA injection prevented stricture formation after ESD in low-risk patients but was not sufficient to prevent stricture in high-risk patients. Additional interventions should thus be considered in high-risk patients. |
Same-session Double EUS-bypass versus Surgical Gastroenterostomy and Hepaticojejunostomy: An International Multicenter Comparison. Despite being used in a patient population with more comorbidities, same-session double EUS-bypass achieved similar technical and clinical success, and was associated with fewer overall and severe adverse events when compared to surgical gastroenterostomy and hepaticojejunostomy. |
| Gut |
MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis. Here, we investigated the roles of MCPIP1 in modulating the differentiation and functions of intestinal macrophages in the pathogenesis of IBD. Design ScRNA-seq was used to cluster the monocyte/macrophage lineage from macrophage-specific deficiency polarises macrophages towards M1-like phenotype, arrests macrophage maturation and exacerbates intestinal inflammation in an Atf3-Ap1s2-dependent manner, thus providing novel mechanistic insight into intestinal macrophage functions during IBD. |
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma. We uncover an adaptive transcriptional programme by which tumour cells evade immune-checkpoint targeting via PPAR |
| Hepatology |
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans. The systemic ASBT inhibitor A3907 improved experimental cholestatic disease by targeting ASBT function at the intestinal, liver and kidney levels, resulting in marked clearance of circulating BAs and liver protection. A3907 is well-tolerated in humans, supporting further clinical development for the treatment of cholestatic liver diseases. |
Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition. ApoJ antagonist peptide might be a potential therapeutic against lipid-associated metabolic disorders through restoring mTOR and FBW7 interaction and facilitating ubiquitin-proteasomal degradation of mTOR. |
Antisense oligonucleotide silencing of a glycosyltransferase, Poglut1, improves the liver phenotypes in mouse models of Alagille syndrome. Our preclinical studies establish ASO-mediated POGLUT1 knockdown as a potential therapeutic strategy for ALGS liver disease and possibly other diseases associated with BD paucity. |
Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system. Baseline NS5A-RAS can compromise the efficacy of double-DAA pangenotypic regimens for HCV genotype 3 and enhanced viral fitness can accelerate treatment failure. Persistence of RAS after successive treatment failure is facilitated by the remarkable evolutionary capacity and plasticity of the HCV genome. Proof-of-concept for the potential development of multi-DAA resistance is shown. |
Cost effectiveness of MRE vs VCTE in staging fibrosis for non-alcoholic fatty liver disease (NAFLD) patients with advanced fibrosis. MRE was not only cost effective than VCTE as the frontline modality for staging NAFLD patients with FIB-4=2.67 with ICER of $7048/QALY but also remained cost effective when used as a follow-up in instances of VCTE failure to diagnose. |
Deficiency of neutrophil high-mobility group box protein-1, in liver transplant recipients, exacerbates early allograft injury in mice. Neutrophil HMGB1 from recipients is central to regulate their activation, limiting production of ROS and pro-inflammatory cytokines, and protects from early liver allograft injury. |
Emerging role of statin therapy in the prevention and management of cirrhosis, portal hypertension, and HCC. We also review evidence to date regarding the effects of statins on portal hypertension and in chemoprevention of HCC. Finally, we highlight ongoing prospective randomized controlled trials that we expect will expand our understanding of the safety, pharmacokinetics, and efficacy of statins in cirrhosis and guide clinical practice. |
Epigenetic regulation of HBV-specific tumor infiltrating T cells in HBV-related HCC. This study provides insight into the cellular and molecular basis of the epigenomic programs that regulate the differentiation and generation of HBV-related T cells from viral infection and HBV + HCC unique immune exhaustion. |
Ferroptosis in hepatocellular carcinoma: from bench to bedside. On the other hand, having ferroptosis affect HCC cells might be desirable. This review examines the role of ferroptosis in HCC from cellular, animal, and human perspectives, while examining its mechanisms, regulation, biomarkers, and clinical implications. |
Global and national prevalence of nonalcoholic fatty liver disease in adolescents: an analysis of the global burden of disease study 2019. NAFLD in adolescents is an increasing health problem on al continents. Improving environmental factors, including lifestyle but also healthcare policies, can help to prevent NAFLD from developing in children and adolescents and help to improve outcomes in children and adolescents with NAFLD. |
Hepatocellular carcinomas, exhibiting intratumor fibrosis, express cancer-specific extracellular matrix remodeling and WNT/TGFB signatures, associated with poor outcome. Matrisome analysis highlighted cancer-specific ECM deposits, typical of the WNT/TGFB HCC subclass, associated with poor patient outcome. Hence, histological reporting of intratumor fibrosis in HCC is of clinical relevance. |
Heterogeneity, crosstalk and targeting of cancer associated fibroblasts in cholangiocarcinoma. Despite their overall tumor promoting role, recent evidence indicates the presence of transcriptional and functional heterogeneous CAF subtypes with tumor promoting and tumor restricting properties. To elucidate the complexity and potentials of CAFs as therapeutic targets in CCA, this review will discuss the origin of CAFs, their heterogeneity, crosstalk, and role during tumorigenesis thus, providing an overall picture of the present and future perspectives of CAFs in CCA. |
Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study. Detection of NASH and at-risk NASH can be improved by constructing independent ML models for each component, using only clinical predictors. Adding biomarkers only improved accuracy for fibrosis. |
Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis. These results demonstrate that membrane PL composition modulates the progression of NASH and that manipulating LPCAT3 expression could be an effective therapeutic for NASH. |
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. We have identified a pathway which requires the presence of functional mitochondria for TGF-ß to mediate HSC transcriptional regulation and transdifferentiation, and therefore provides a key link between bioenergetic capacity of HSC and signals for transcriptional up-regulation of genes of anabolic pathways. |
Obstacles to implement machine perfusion technology in routine clinical practice of transplantation - Why are we not there yet ? The role of research development, clear regulatory pathways and the need for more flexible reimbursement schemes is discussed together with potential solutions to address most relevant hurdles. This article paints an overall picture of the current liver perfusion landscape and highlights the role of clinical, regulatory and financial stakeholders worldwide. |
Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis. Our findings indicate that persistent activation of mTORC1 due to the loss of cholangiocyte TSC1 promotes hepatomegaly, liver cell repopulation, DR, inflammation, fibrosis and liver injury in Gao-binge alcohol fed L-Tsc1 KO mice, which phenocopy the pathogenesis of human AH. |
Phase 2 trial of bintrafusp alfa as second-line therapy for patients with locally advanced/metastatic biliary tract cancers. Although this study did not meet its prespecified primary endpoint, bintrafusp alfa demonstrated clinical activity as second-line treatment in this hard-to-treat cancer, with durable responses and a manageable safety profile. |
Quantifying days at home in patients with cirrhosis: a national cohort study. In this national study, we found that patients with cirrhosis spend as many, if not more, cumulative days receiving post-acute, emergency, and observational care, as hospitalized care. Ultimately, up to two months of DAH are lost annually with onset of liver decompensation. DAH may be a useful metric for patients and health systems alike. |
Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury. These data show that HNF4a interacts with Nrf2 and promotes GSH replenishment aiding in recovery from APAP-induced liver injury, a process inhibited by cMyc. These studies indicate that maintaining HNF4a function is critical for regeneration and recovery after APAP overdose. |
Role of sex in liver tumor occurrence and clinical outcomes: a comprehensive review. Available data on the roles of sex hormones and gender differences in liver tumor occurrence and clinical outcomes are conflicting. Here, we critically review the main gender-based differences in the molecular mechanisms associated with liver carcinogenesis and the prevalence, prognosis, and treatment of primary and metastatic liver tumors. |
Single-cell and spatially resolved transcriptomics for liver biology. We highlight recent progress in the liver cell atlas that characterizes the comprehensive cellular composition, diversity and function; the spatial architecture, such as liver zonation, cell communication and proximity; the cell identity conversion and cell-specific alterations that are associated with liver pathology; and new therapeutic targets. We further discuss outstanding challenges, advanced experimental technologies and computational methods helping to address these challenges. |
Virological characterization of treatment failures and retreatment outcomes in patients infected with "unusual" HCV genotype 1 subtypes. Patients infected with "unusual" HCV genotype 1 subtypes are overrepresented among DAA treatment failures. Most of them were born and likely infected in sub-Saharan Africa. "Unusual" HCV GT-1 subtypes naturally carry polymorphisms that confer reduced susceptibility to the drugs currently used to cure hepatitis C, in particular the NS5A inhibitors. Retreatment with sofosbuvir plus an NS3 protease and an NS5A inhibitor is generally efficacious. |
| J Hepatol |
A proposal from the Liver Forum for the management of comorbidities in nonalcoholic steatohepatitis therapeutic trials. For the latter, we analyzed non-hepatological co-morbid conditions for changes or acute events possibly occurring during the trial, including changes in alcohol consumption, in order to suggest when specific interventions are necessary and how to manage concomitant drug intake in line with methodological constraints. These recommendations are open to further refinement when additional data will become available and intend to provide a guide for clinical trialists in order to achieve optimal trial objectives while maintaining overall patient health and safety during the trial. |
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. Despite ATF4 being upregulated in established HCC, it serves an important protective function in normal hepatocytes. By maintaining glutathione production ATF4 inhibits ferroptosis-dependent inflammatory cell death, which is known to promote compensatory proliferation and hepatocarcinogenesis. Ferroptosis inhibitors or ATF4 activators may also blunt HCC onset. |
Healthcare affordability and effects on mortality among adults with liver disease from 2004-2018 in the United States. Adults with liver disease face greater financial distress than adults without liver disease, adults with cancer history. Financial distress is associated with increased risk of all-cause mortality among adults with liver disease. Interventions to improve healthcare affordability should be prioritized in this population. |
Hepatopulmonay syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod. Plasma S1P levels are low in patients with hepatopulmonary syndrome, more so in severe cases. Fingolimod, by improving pulmonary vascular tone and oxygenation improves survival in murine CBDL-HPS model. Impact and implications 1. Low level of plasma sphingosine-1-phosphate (S1P) is associated with severe pulmonary vascular shunting and hence, it can serve as a marker of disease severity in patients with hepatopulmonary syndrome (HPS).2. Fingolimod, a functional agonist of S1P, reduces hepatic inflammation, improves vascular tone thus retards the progression of fibrosis in preclinical animal model of HPS.3. Fingolimod is being proposed as a potential novel therapy for management of patients with HPS. |
| J Neurogastroenterol Motil |
Heart Rate Variability and Somatization in Adolescents With Irritable Bowel Syndrome. Adolescents with IBS showed signs of autonomic dysfunction only during the orthostatic test, which were associated with increased somatization scores. Further research is needed to establish the links between emotional wellbeing and autonomic function in this population. |
Hypercontractile Esophagus: Clinical and Manometric Features From a Multicenter Korean Cohort. Sixty-one percent of patients who meet the diagnostic criteria for the high-resolution manometry are diagnosed with symptomatic HE based CC v4.0. Chest pain and regurgitation were also observed in over half of them. The overall medical treatment efficacy was moderate. |
Prevalence of Irritable Bowel Syndrome in Japan, China, and South Korea: An International Cross-sectional Study. The overall prevalence of IBS in the 3 countries was slightly higher than the global prevalence, and it was significantly lower in China than in Japan and South Korea. IBS prevalence was the highest and lowest among individuals in their 40s and 60s, respectively. Male individuals had a higher prevalence of IBS with diarrhea. Further studies are needed to elucidate the factors associated with this regional heterogeneity. |
Prevalence of Non-erosive Esophageal Phenotypes in Children: A European Multicenter Study. FH may be the most common pediatric NEEP. At long-term follow-up, there was a trend toward a more frequent complete symptom resolution with PPI-therapy in NERD patients while other groups did not benefit from extended acid-suppressive-treatment. |
Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice. The diabetic oxidative stress-induced upregulation of CK2 contributed to modulating SK3 channel sensitivity to Ca 2+ in colonic PDGFRa + cells, which may result in colonic dysmotility in diabetic mice. |
Pyloric Functional Lumen Imaging Probe Measurements Are Dependent on Balloon Position. FLIP balloon position within the pylorus directly affects balloon geometry which significantly affects P, CSA, and DI measurements. Standardized pyloric FLIP protocols and balloon design adjustments are needed for the continued application of this technology to the pylorus. |
Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study. These results support the notion that host-specific parameters such as WGTT and microbiota composition should be considered when designing studies involving probiotics, especially for the optimization of washout duration in crossover studies but also for the definition of enrollment criteria or supplementation regimen in specific populations. |
Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks. These new and complementary datasets provide a valuable molecular framework for further understanding how ICC pacemaker activity regulates smooth muscle contraction in both normal GI tissue and GI motility disorders. |
| Neurogastroenterol Motil |
Comparisons of the Rome III and Rome IV criteria for diagnosis of irritable bowel syndrome in Indian and Bangladeshi communities and internal shifts in the diagnostic categories of bowel disorders of gut-brain interactions. The Rome IV diagnostic criteria for IBS are less sensitive than the Rome III criteria in Indian and Bangladesh communities. Application of the Rome IV criteria to people who meet the Rome III IBS criteria selects a subgroup of people with greater severity of symptoms, and hence, Rome IV IBS is more strongly associated with physician consultation. These findings may have important bearing in future iterations of the Rome criteria for a broader global applicability. |
Effects of treatment cessation and re-treatment in randomized controlled trials of prucalopride in patients with chronic idiopathic constipation. Prucalopride cessation resulted in a loss of clinical effect to baseline levels within 7 days. Similar efficacy and safety were observed between TP1 and TP2 after prucalopride was re-initiated following a washout period. |
Epidemiology of disorders of gut-brain interaction in Belgium and differences between two language groups: Results from the Rome foundation global epidemiology study. & interferences The results of this first in-depth analysis of Rome IV DGBI in Belgium show a higher prevalence for some DGBI in the French-speaking cohort, and a larger associated disease burden. These differences between language/culture groups in the same country support the psychosocial pathophysiological model of DGBI. |
Face-to-face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population-based research. The findings strongly indicate that besides affecting data quality, manpower needs and data collection time and costs, the choice of survey method is a substantial determinant of symptom reporting and DGBI prevalence outcomes. This has important implications for future DGBI research and epidemiological research more broadly. |
Medical students' knowledge and perception of irritable bowel syndrome in comparison to inflammatory bowel disease. Biases observed in gastroenterologists toward patients with IBS originate as early as the beginning of medical school, including seeing IBS as a "less real" disease and more difficult to treat. Earlier educational interventions may be helpful in identifying and addressing these biases. |
Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine. Background Enterochromaffin (EC) cell-derived 5-hydroxytryptamine (5-HT) is a mediator of toxin-induced reflexes, initiating emesis via vagal and central 5-HT receptors mediated both 5-HT and incretin mucosal responses in healthy colon. |
Pictograms to assess bloating and distension symptoms in the general population in Mexico: Results of The Rome Foundation Global Epidemiology Study. Pictograms are more effective than VDs for assessing the presence of bloating/distension in Spanish Mexico. Therefore, they should be used to study these symptoms in epidemiological research. |
Prevalence and description of disorders of gut-brain interaction in Spain according to the results of the Rome Foundation Global Epidemiology Study. We provide the first comprehensive data on the prevalence and burden of al DGBI in Spain using the Rome IV criteria. The enormous burden of DGBI in Spain highlights the need for specialized training and future research. |
Prevalence and impact of disorders of Gut-Brain interaction in Sweden. DGBI prevalence and its impact in Sweden is in line with global data, including increased healthcare utilization. GI symptoms are commonly affected by psychological factors and eating, and a high proportion of those on prescription medication report sufficient GI symptom relief. |
The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: Results from the Rome foundation global epidemiology study. The prevalence and burden of DGBI is consistently high in the UK and in the rest of the world. Opioid prescribing, cultural, dietary, and lifestyle factors may contribute to differences in the prevalence of some DGBI between the UK and other countries. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: Practical considerations for fluid resuscitation in cirrhosis. The absence of consistent evidence for fluid resuscitation in patients with cirrhosis limits our ability to produce a clearly evidence-based protocol for fluid resuscitation in cirrhosis. However, we propose a preliminary practical guide to managing fluid resuscitation in patients with decompensated cirrhosis. Further studies are needed to develop and validate volume assessment tools in the specific context of cirrhosis, while randomised clinical trials of protocolized resuscitation may improve care of this patient population. |
| Gastroenterology |
| Gut |
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease. Single-cell transcriptomics and related spatial approaches have identified previously undescribed epithelial and stromal cell types and states, how these populations change with disease progression, and potential mechanisms of action which will serve as the basis for designing new therapeutic strategies. Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression. |
| J Hepatol |
Global burden of Liver Disease: 2023 Update. This iteration of the global burden of liver disease is an update of the 2019 version and focuses mainly on areas where significant new information is available like alcohol-associated liver disease, NAFLD, viral hepatitis, and HCC. We also devote a separate section to the burden of liver disease in Africa, an area of the world typically neglected in such documents. |
Hepatology Genome Rounds: An interdisciplinary approach to integrate genomic data in clinical practice. We describe our single-center experience and discuss practical considerations for clinicians interested in launching such a series. We foresee that this format will be adopted at other institutions and in additional specialties for further incorporation of genomic information in clinical medicine. |
| J Neurogastroenterol Motil |
Achalasia: The Current Clinical Dilemma and Possible Pathogenesis. In this paper, epidemiology, diagnosis treatment, as well as possible pathogenesis of achalasia will be reviewed and summarized. The proposed hypothesis on the pathogenesis of achalasia is that genetically susceptible populations potentially have a higher risk of infection with viruses, triggering autoimmune and inflammation responses to inhibitory neurons in lower esophageal sphincter. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Neurogastroenterol Motil |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gut |
| J Hepatol |
| J Neurogastroenterol Motil |
| Neurogastroenterol Motil |